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프라그마틱 카지노 are studies designed to provide information for the real-world practice of clinical. They are typically described by their focus on practical aspects of study design which include recruitment and consent, adherence and the use of standard equipment.
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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.
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The goal of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. Usually, they are requested by practitioners and policymakers to inform their decisions. They are also a good method to determine the causality between an intervention and its outcomes. However, they shouldn't be used as a substitute for explanation trials.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.